Yes, Marshall speakers are designed to be used with guitar amplifiers. They are made to handle the high power output and frequency range of electric guitars. Marshall makes a wide range of speakers that are suitable for different types of guitar amplifiers, such as combo amps, heads, and cabs. If you are looking to replace the speakers in your Marshall amplifier, it is important to choose a speaker that is compatible with the power output and impedance of your amp. You should also consider the size of the speaker and the type of sound you want to achieve. It is generally a good idea to consult the manufacturer's specifications or consult with a professional before making any changes to your amplifier.